Prognostic Role of Long Noncoding RNA BANCR in Solid Tumors: A Meta-Analysis
نویسندگان
چکیده
Accumulating studies have reported that long noncoding RNA BRAF-activated nonprotein coding RNA plays vital role in various cancers. However, the prognostic values of BRAF-activated nonprotein coding RNA in solid tumors remain controversial. Thus, we assessed the prognostic values of BRAF-activated nonprotein coding RNA by this meta-analysis. We comprehensively searched PubMed, Web of Science, Medline, China National Knowledge Infrastructure (CNKI), and the Cochrane Library at November 2016. After carefully screening, we ultimately included 14 studies in this meta-analysis. This meta-analysis brought all relevant articles into determining the association of BRAF-activated nonprotein coding RNA expression with overall survival and clinicopathologic features. The results showed that high BRAF-activated nonprotein coding RNA expression significantly shorten the overall survival of solid tumors (pooled hazard ratios 1.66, 95% confidence interval: 1.19-2.32). Moreover, high BRAFactivated nonprotein coding RNA expression was also strongly associated with advanced tumor stage (odds ratios 1⁄4 2.57, 95% confidence interval: 1.14-5.79), differentiation grade (odds ratio 1⁄4 1.71, 95% confidence interval: 1.26-2.31), lymph node metastasis (odds ratio 1⁄4 2.67, 95% confidence interval: 1.93-3.70, P < .001), and distant metastasis (odds ratio 1⁄4 2.98, 95% confidence interval: 1.76-5.07, P 1⁄4 .02). In conclusion, this meta-analysis demonstrated that high BRAF-activated nonprotein coding RNA expression may be a potential novel biomarker for indicating a poor prognosis and progression in human solid tumors.
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